Age-It identifies the ten most relevant challenges to allow individuals to age well and to build an inclusive ageing society as the foundation of the Spoke infrastructure, which consists of six thematic (horizontal) challenges and four cross-integration (vertical) challenges.

• The project originates from the demographic megatrends that are shaping our society: the first challenge is thus the understanding of the micro and macro demographic drivers of ageing adopting a Data Science approach to decision-making (#1).
• Addressing and facing population ageing necessitates a focus on pivotal thematic challenges: improving our understanding of the biology of ageing(#2), of the clinical and functional factors related to multimorbidity (#3), of the life course trajectories of active and healthy ageing (#4), and of the world of care provision (#5). These challenges are intertwined with the Silver Economy (i.e., work, participation and welfare at older ages, but also new consumption and activity models) (#6) and with the political and cultural dimensions of an ageing society (#7).
• The thematic challenges are systematically integrated by three additional cross-integration challenges: The importance of interventions and technologies to reduce the burden of age-related diseases, disorders and disabilities (#8), the technological developments towards meeting the (new) needs of older people (#9), as well as the overall mainstreaming and re-thinking of ageing-related policy-making (#10).